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Tough Spots are ideally used for labeling 0.5ml, 1.5ml and 2.0ml micro centrifuge tubes. Tough Spots can withstand freezer temperatures down to -196°C (liquid and vapor phase nitrogen), boiling water bath (100°C), autoclaving and moderate oven temperature (150°C). Tough Spots can endure sustained humidity and soaking , submersion in boiling water bath, autoclaving, organic solvents, caustic agents and other challenges without peeling, degrading or becoming brittle.